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Free NCLEX-RN Pharmacology Practice Questions

Pharmacological and Parenteral Therapies is one of the largest sections of the NCLEX-RN test plan. These free practice questions cover medication administration, adverse effects, and high-alert drugs — each with a full rationale.

Q1

A client is prescribed insulin glargine (Lantus). Which statement by the client indicates a need for further teaching?

AI will inject this insulin at the same time every day
I will mix this insulin with my regular insulin to reduce injections
CI will rotate injection sites within the same body area
DI will not skip doses even if I am not eating well

RATIONALE

Insulin glargine (Lantus) is a long-acting insulin that must NEVER be mixed with other insulins. Mixing alters its pharmacokinetics and can cause unpredictable blood glucose control.

Q2

A client on warfarin (Coumadin) has an INR of 5.2. Which action should the nurse anticipate?

AAdminister the next scheduled dose as ordered
BIncrease the warfarin dose
Prepare to administer vitamin K
DAdminister protamine sulfate

RATIONALE

A therapeutic INR for most clients on warfarin is 2–3. An INR of 5.2 indicates a high bleeding risk. Vitamin K is the antidote for warfarin. (Protamine sulfate reverses heparin, not warfarin.)

Q3

A client receiving furosemide (Lasix) should be monitored most closely for which electrolyte imbalance?

AHypercalcemia
Hypokalemia
CHypernatremia
DHypermagnesemia

RATIONALE

Furosemide is a loop diuretic that causes significant potassium loss. Hypokalemia can lead to cardiac dysrhythmias and increases the risk of digoxin toxicity. Monitor potassium and encourage potassium-rich foods.

Q4SATA

Which findings indicate digoxin toxicity? Select all that apply.

Nausea and vomiting
Visual disturbances (yellow-green halos)
Bradycardia
DIncreased appetite
EHypertension

RATIONALE

Early digoxin toxicity presents with nausea, vomiting, anorexia (not increased appetite), visual changes such as yellow-green halos, and bradycardia. Hypokalemia potentiates toxicity.

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